The short answer to your question is "yes" since Program Management Agreements (PMA) are initiated/signed before milestone reviews are conducted. PMA are part of the documentation establishing a program and assigning the program manager.
Program Management Agreements (PMA) are required IAW DoDI 5000.02, Enclosure 10 and are prepared for ACAT I and II programs after the Air Force makes the investment decision to pursue a new program and the PM has been assigned. This administrative action will occur before milestone reviews. The PM, the CAE, and the requirements and, where applicable, resource authorities sign the agreement. PMAs shall be updated annually or more frequently if the conditions that formed the basis for the agreement (e.g., requirements, funding, or execution plans) have changed. DoDI 5000.02 encourages PMAs for ACAT III programs.